DHM 98% · HPLC-tested · From vine tea

Dihydromyricetin (DHM) Bulk Powder Supplier

  • 98% DHM by HPLC
  • Vine tea leaf, Hunan, China
  • Batch COA on request
  • 2-year shelf life

Tianyi Health Tech supplies bulk dihydromyricetin (DHM, also known as DMY or ampelopsin) powder to supplement brands, private-label manufacturers and functional beverage companies. Our 98% DHM (HPLC) is extracted from the young leaves of vine tea (Ampelopsis grossedentata) grown in Hunan, and is supplied with batch COA and OEM/ODM support.

Dihydromyricetin (DHM) crystal illustration

Specification

Dihydromyricetin (DHM) 98% Specification

Typical specification (batch COA available on request)
ParameterTypical specificationMethod
Identity
Product nameDihydromyricetin (DHM)
SynonymsDMY; ampelopsin; dihydromyricin
CAS No.27200-12-0
Molecular formula / weightC15H12O8 / 320.25 g/mol
Botanical sourceAmpelopsis grossedentata (vine tea), young leaves
OriginHunan, China
Specification
Assay (DHM)NLT 98%HPLC
AppearanceWhite, fine powderVisual / organoleptic
Loss on dryingNMT 5%105 °C, 4 h
AshNMT 5%525 °C, 3 h
Particle size100% pass 80 meshSieve
Residual solvents≤ 0.5%GC
Contaminants and microbiology
Heavy metals (total)≤ 10 mg/kgAAS
Lead (Pb) / Arsenic (As)≤ 2.0 / ≤ 1.0 mg/kgAAS
Mercury (Hg) / Cadmium (Cd)≤ 1.0 / ≤ 1.0 mg/kgAAS
Total plate count≤ 1,000 cfu/gPharmacopoeia method
Yeast and mold≤ 100 cfu/gPharmacopoeia method
Salmonella / E. coliNegative / NegativePharmacopoeia method
Aflatoxin B1≤ 5.0 µg/kgPharmacopoeia method
Pesticide residues (BHC, DDT, PCNB / aldrin)≤ 0.10 / ≤ 0.02 mg/kgPharmacopoeia method
Physical and handling data
Bulk / tapped densityAbout 0.25 g/mL / 0.34 g/mL
Capsule fillAbout 0.32 g DHM per size 00# capsule (0.95 mL)
SolubilityEasily soluble in hot water; much lower at room temperature
StabilityStable in neutral and slightly acidic conditions; avoid temperatures above 100 °C (irreversible oxidation)
Supply
Packaging1–5 kg: inner sealed bag, outer foil bag, carton. Above 5 kg: inner double PE bag in a paper/fibre drum
Shelf life / storage2 years in original unopened packaging; ventilated, dry place away from direct sunlight and heat
DocumentsSpecification sheet, batch COA and technical documents on request

Values are typical specification limits. The batch COA supplied with each order prevails. Looking for a lower-purity total-flavonoid grade? See vine tea extract.

Overview

What Is Dihydromyricetin (DHM)?

Dihydromyricetin (DHM) is a dihydroflavonol found in vine tea, the leaves of Ampelopsis grossedentata. It also appears in the literature as DMY, ampelopsin and dihydromyricin, and is registered under CAS 27200-12-0. Young vine tea leaves are unusually rich in it, with reported contents of up to 20–30%, which is why vine tea is the practical commercial source. To buy the whole-leaf flavonoid extract instead of the purified compound, see our vine tea extract, or compare both grades in our formulator guide: Dihydromyricetin (DHM) vs Vine Tea Extract: Differences, Specifications and Sourcing.

Our DHM is purified by repeated crystallization to a specification of at least 98% by HPLC (detection at 291 nm), giving a white powder that is easy to standardize in capsules, stick packs and powdered drink mixes.

Scientific advisor. Our vine tea program is advised by Dr. Zhang Yousheng, research fellow, author of Vine Tea Science and chief research expert for Zhangjiajie vine tea (mei cha).

Research

Why Brands Formulate With DHM

DHM is one of the most studied vine tea constituents. Published research, mostly preclinical, has examined its antioxidant behavior, its interaction with neurotransmitter receptors, and its role in liver lipid and ethanol metabolism pathways. The references below are provided for R&D reference only. They describe research and are not claims about our product.

Selected references

  1. Shen Y, Lindemeyer AK, Gonzalez C, et al. Dihydromyricetin as a novel anti-alcohol intoxication medication. J Neurosci. 2012;32(1):390–401. doi:10.1523/JNEUROSCI.4639-11.2012. Preclinical study of DHM and GABA-A receptors.
  2. Silva J, Yu X, Moradian R, et al. Dihydromyricetin protects the liver via changes in lipid metabolism and enhanced ethanol metabolism. Alcohol Clin Exp Res. 2020;44(5):1046–1060. doi:10.1111/acer.14326. Preclinical study.
  3. Zhang J, Chen Y, Luo H, et al. Recent update on the pharmacological effects and mechanisms of dihydromyricetin. Front Pharmacol. 2018;9:1204. doi:10.3389/fphar.2018.01204. Review article.

Formulation guide

Formulating With DHM Powder: Solubility, Stability and Capsule Fill

DHM behaves differently from most plant extracts, so a few handling facts save weeks of trial and error. The notes below come from our own physical data and are a starting point for your lab work.

Solubility

DHM is easily soluble in hot water and much less soluble at room temperature. For beverages and liquid concentrates, dissolve in hot water first, then cool and blend into the base. For cold-mix powdered drinks, plan for dispersion rather than full dissolution and test the finished texture.

Stability and pH

DHM is stable under neutral and slightly acidic conditions and has good thermal stability, but above 100 °C it oxidizes irreversibly. Keep processing below boiling and avoid long hot holds. Validate pH, light and shelf-life stability in your own matrix.

Capsule fill

About 0.32 g of DHM fills one size 00# capsule (0.95 mL), so a 300 mg-class serving fits in one capsule without much excipient. Our powder is light (bulk about 0.25 g/mL, tapped about 0.34 g/mL), so check flow and tamping on your filling line.

Stick packs and powder blends

100% of the powder passes 80 mesh, which suits dry blending with sweeteners, acids and flavors.

Dose design. Finished supplements are commonly formulated at around 300 mg per serving. Final dose, labeling and any wording must follow the rules of your target market and your own substantiation. We can share the technical data we hold to support your regulatory review.

Process

How Our DHM Is Made

  1. ExtractionYoung vine tea leaves are extracted to release the flavonoid fraction.
  2. CrystallizationCooling crystallization and filtration separate crude DHM crystals.
  3. RecrystallizationAlcohol precipitation and recrystallization from water raise purity.
  4. Activated carbonActivated carbon treatment and repeated crystallization refine color and purity.
  5. Drying and packingThe crystals are dried, sieved and packed in food-grade bags and drums.

Purification relies on repeated crystallization. Residual solvents are specified at 0.5% or less and tested by GC.

OEM / ODM

OEM/ODM & Custom Solutions

Why Tianyi

Why Partner With Tianyi

Vine tea expertise

A Hunan vine tea supply base and a scientific advisor who wrote the textbook on vine tea, Vine Tea Science.

Batch-level documentation

Specification sheet and batch COA on request, with HPLC assay, heavy metals, microbiology and residual solvents.

Responsive technical support

A named export contact, replies within 24 hours, and formulation guidance on dissolving and stabilizing DHM.

One source for both grades

Buy DHM 98% here, or the whole-leaf vine tea extract if you need a total-flavonoid profile.

Quality

Quality Control & Certifications

Each batch is tested for DHM assay by HPLC, loss on drying, ash, particle size, residual solvents, heavy metals (AAS), microorganisms, aflatoxin B1 and selected pesticide residues, as listed in the specification above. A batch COA is available on request, and the HPLC chromatogram can be shared with the COA.

Company-level credentials and partner certificates are listed on our Quality & Certifications page.

FAQ

Frequently Asked Questions

Are DHM, DMY and ampelopsin the same ingredient?

Yes. Dihydromyricetin (DHM), DMY, ampelopsin and dihydromyricin are names for the same dihydroflavonol (CAS 27200-12-0). Buyers and formulators use them interchangeably; please use whichever term your documentation requires and we will match it on the COA.

What purity of dihydromyricetin do you supply?

Our standard grade is DHM 98% (HPLC), a white fine powder. Assay is specified as not less than 98%. For a lower-purity total-flavonoid grade, see our vine tea extract, or compare specifications and formulations in our DHM vs vine tea extract guide.

How do I dissolve DHM powder in a drink?

DHM is easily soluble in hot water and much less soluble at room temperature, so dissolve it in hot water (below 100 °C) and then cool or blend into your base. DHM is stable in neutral and slightly acidic conditions, but above 100 °C irreversible oxidation occurs, so avoid prolonged boiling. Always validate stability in your own matrix and pH.

How much DHM fits in a capsule?

One size 00# capsule (0.95 mL) holds about 0.32 g of our DHM powder. Bulk density is about 0.25 g/mL and tapped density about 0.34 g/mL, which is lighter than many botanical powders, so allow for this when sizing capsules, drums and shipments.

Can I get a COA and samples before ordering?

Yes. A batch COA and a specification sheet are available on request, and samples can be arranged for formulation and lab testing. Use the quote form or email us and we reply within 24 hours.

What are the packaging, shelf life and storage conditions?

1–5 kg: sealed inner bag in a foil bag, packed in a carton. Above 5 kg: double PE inner bag in a paper/fibre drum. Shelf life is 2 years in unopened original packaging, stored dry and ventilated, away from direct sunlight and heat.

What is the regulatory status of DHM in the US and EU?

Regulatory status varies by market and by intended use (for example, new dietary ingredient considerations in the US and novel food assessment in the EU). We provide technical documentation, but the brand is responsible for confirming compliance and labeling in its target market.

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Last updated: 13 October 2026

Research and clinical information is provided for R&D and B2B reference only. These statements have not been evaluated by the Food and Drug Administration. Our ingredients are not intended to diagnose, treat, cure or prevent any disease. Final specifications and regulatory status are confirmed per commercial agreement.